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Fatty Liver

NAFLD (Non-alcoholic Fatty Liver Disease)

NAFLD encompasses a spectrum of disease states, from steatosis (fatty liver) to non-alcoholic steatohepatitis (also called NASH; steatosis with inflammatory changes) followed by progression to fibrosis, cirrhosis and hepatocellular carcinoma. Excess liver fat is believed to be a manifestation of the metabolic syndrome and not surprisingly NASH is associated with obesity, insulin resistance, dyslipidemia and type II diabetes in humans. Most obese adults have hepatic steatosis and at least one-third of these individuals will eventually develop worsening NAFLD. Therefore, the prevalence of NAFLD will likely rise with obesity rates.

As with many human diseases, fatty liver in rodents is also diet-inducible. Different dietary approaches produce different severities of disease along the NAFLD spectrum and likely work by unique mechanisms. Therefore it is important for the researcher to choose the diet that best suits the needs of their study. Contact one of our scientists for advice. To read more, see our Product Literature.

Types of Diets methionine and choline deficient (MCD) diet, choline-deficient diet (CD), high-fat diet (HFD)
Commonly Used Strains C57BL/6, LDLR (-/-) mice, Sprague Dawley rats
Matched Control Diet Purified Ingredient match*

*For those requiring a matched control diet, be sure to use a purified ingredient matched diet rather than a grain-based diet.

Product Literature

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Sara 1045

Sara Sturgess, M.S., R.D.N.

Project Manager and Scientist
Steve 6623

Steven Yeung, M.S.

Project Manager and Scientist
Holly 0947

Jia-Yu (Holly) Ke, Ph.D.

Project Manager and Scientist