Purified diets, with amino acids as the protein source

By Sridhar Radhakrishnan, Ph.D..

The ease of modifying purified diets, with amino acids as the protein source, allowed to make such formulations that could be used in lieu of complex procedures like myeloablation and could make the process of HSCs engraftment an easy procedure in rodents.

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Research Diets’ own Dr. Laura Griffin publishes paper showing that use of genetically diverse mouse strains may help translatability to humans

By Laura Griffin, Ph.D..

Despite evidence suggesting that natural products protect against obesity and metabolic syndrome in cell culture and animal models, results oftentimes do not translate in human clinical trials. One possible explanation for this finding is the...

laura

Publication: A Translational Mouse Model for NASH

By Sridhar Radhakrishnan, Ph.D..

An interesting publication using NASH diets ...

A Translational Mouse Model for NASH with Advanced Fibrosis and Atherosclerosis Expressing Key Pathways of Human Pathology

Anita M. van den Hoek 1,*, Lars Verschuren 2, Nicole Worms 1, Anita van...

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Targeted Nutrient Modifications in Purified Diets Differentially Affect Nonalcoholic Fatty Liver Disease and Metabolic Disease Development in Rodent Models

By Sridhar Radhakrishnan, Ph.D..

Sridhar Radhakrishnan, Jia-Yu Ke, Michael A Pellizzon
Current Developments in Nutrition, Volume 4, Issue 6, June 2020

ABSTRACT
Nonalcoholic fatty liver disease (NAFLD) is a complex spectrum of disorders ranging from simple benign steatosis to more...

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Choice of Laboratory Rodent Diet May Confound Data Interpretation and Reproducibility

By Michael A. Pellizzon, Ph.D..

Michael A Pellizzon and Matthew R Ricci
Research Diets, Inc, New Brunswick, NJ, USA

ABSTRACT
The reproducibility of experimental data is challenged by many factors in both clinical and preclinical research. In preclinical studies, several factors...

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The biggest study that's been done in mouse nutrition in 50 years by John Speakman, PhD

By Mark D'Antonio.

In a landmark paper published in Cell Metabolism in September of 2018,  John Speakman, (with joint appointments at University of Aberdeen and the Chinese Academy of Sciences) et al., studied the effects of 29 different diets that varied in...

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The common use of improper control diets in diet-induced metabolic disease research confounds data interpretation: the fiber factor

By Mark D'Antonio.

Diets used to induce metabolic disease are generally high in fat and refined carbohydrates and importantly, are usually made with refined, purified ingredients. However, researchers will often use a low fat grain-based (GB) diet containing...

mark