In 2008, Kozul-Horvath and Hamilton’s found that mice fed a grain-based chow (Purina 5001) had no changes in gene expression when exposed to arsenic while they were dramatic when fed purified diet AIN-76A (Click here for pdf...

William Lagakos, Ph.D. - Project Manager and Scientist
Bill received a Ph.D. in nutritional biochemistry and physiology from Rutgers University in 2009, where he studied energy balance and intestinal lipid metabolism with his mentor, Judith Storch,...

My colleague Angela found this paper (Differential Development of Glucose Intolerance and Pancreatic Islet Adaptation in Multiple Diet Induced Obesity Models. Omar, et. al. Nutrients, 2012, 4, 1367-1381.) and it is the first one we know of...

Here's an abstract to a paper written in 1982 about using purified ingredient diets in toxicology research.  The arguments the author makes are still quite valid and apply to other types of research as well.  

A. Wise, Arch Toxicol. 1982...

This paper showed that male and female C57Bl/6 mice gain weight when fed a high fat diet with 60 kcal% fat as mostly lard (i.e. D12492), but only males were insulin resistant and glucose intolerant and developed adipose tissue inflammation....

Lard has been and continues to be used frequently as a fat source in rodent diets, especially for those interested in promoting obesity in susceptible rodent models. This is due to the higher degree of fatty acid saturation of this fat source and...

C57BL/6 mice (baseline 10 wks of age) can have a highly variable weight gain response to D12451 (45 kcal% fat diet) after 16 weeks

Understandably, many customers are concerned about whether our production process involves any extreme temperatures or pressure. This is especially true when we are incorporating a sensitive compound. The answer is, no, diets are not exposed to...

Here's an interesting paper using D12492 (60 kcal% fat) fed mice from the Jackson Labs. These researchers gave the mice synthetic agonists to certain nuclear receptors that are involved in controlling expression of circadian clock proteins....

Automated control limits the researcher's need to visit the animal room, insuring accuracy, reducing stress, and increasing efficiency.